2012 Mercedes-Benz E350: MPG and fuel economy

This page collects every fuel-economy figure the EPA publishes for the 2012 Mercedes-Benz E350. Below you will find the headline combined, city, and highway MPG, the estimated annual fuel cost at three different driving levels, the tailpipe CO₂ emissions, and a full breakdown of the engine and drivetrain. If you want to know whether this generation got more or less efficient over the years, the year-over-year table further down covers every model year the EPA has rated.

Fuel economy at a glance

These are the EPA's official ratings for the 2012 Mercedes-Benz E350. The numbers come from a standardised laboratory test cycle and are the same figures that appear on the window sticker of every new car. Real-world mileage varies with driving style, weather, fuel quality, and how heavily loaded the car is.

Combined MPG is a 55/45 weighted blend of the city and highway test cycles. The EPA uses it as the single number you can compare across the entire dataset, including hybrids and EVs (which use the equivalent MPGe figure).

How the 2012 Mercedes-Benz E350 compares

The 2012 Mercedes-Benz E350 returns 23 combined MPG. Cars in the Midsize Cars class for the same model year average 25.1 MPG, which puts this car behind the class average by about 8%.

The most efficient car in the Midsize Cars class for the 2012 model year is the Nissan Leaf at 99 MPG. The bar chart below puts the Mercedes-Benz E350 alongside the class best and the class average so you can see the full picture.

For broader context, the average new car of the 2012 model year (across all classes) returns 21.7 MPG. Larger vehicles pull the all-cars average down, so do not use that figure on its own to judge a small car or a hybrid. The full list of the most efficient cars of the 2012 model year is on its own page.

Annual fuel cost across driving patterns

The headline annual fuel cost the EPA publishes assumes 15,000 miles of driving per year and a fuel mix of 55% city and 45% highway. The dollar figure is calculated using the EPA's current reference price for premium gasoline, which is $4.61/gallon. EPA updates that reference periodically rather than tracking live pump prices, so treat it as a window-sticker estimate rather than today's pump number.

The table below scales the EPA's number to three common driving patterns. The combined MPG and the reference fuel price stay constant, only the annual mileage changes. To get a current-prices estimate, take your local gas price and multiply by 652.2 gallons (the car's annual consumption at the rated MPG).

Year-over-year MPG for the Mercedes-Benz E350

The EPA has rated the Mercedes-Benz E350 across 17 model years, from 2006 Mercedes-Benz E350 through 2026 Mercedes-Benz E350. The numbers below are the best combined MPG figure the EPA published for each year, which lets you see when the car was at its most efficient and how recent generations stack up.

The 2006 Mercedes-Benz E350 returned 20 MPG. The most recent 2026 Mercedes-Benz E350 returns 28 MPG. That is an improvement of 8 MPG over 20 model years, the kind of gain that usually comes from smaller engines, hybrid systems, or aerodynamic redesigns.

Compare against other Midsize Cars for 2012

If you are cross-shopping the 2012 Mercedes-Benz E350, the most useful comparison is against the other cars in the Midsize Cars class for the same model year. The list below shows the highest-MPG peers, ranked from most to least efficient. Click any of them to open its full page.

The Nissan Leaf leads this group at 99 MPG, 76 MPG ahead of the 2012 Mercedes-Benz E350.

Specifications

The 2012 Mercedes-Benz E350 runs a 3.5-liter 6-cylinder engine paired with a automatic 7-spd, sending power through rear-wheel drive.

Engine, transmission, and drivetrain together drive most of the variation in fuel economy across trims. A larger engine moves the car with less effort but burns more fuel. A turbo lets a small engine punch above its weight, often without much MPG penalty. All-wheel drive adds traction and weight, and usually costs a couple of MPG compared with two-wheel drive of the same engine.

Vehicle class

Midsize Cars

Engine

3.5L 6-cylinder

Transmission

Automatic 7-spd

Drivetrain

Rear-Wheel Drive

Fuel type

Premium

Annual petroleum use

12.9 barrels per year

Common questions about the 2012 Mercedes-Benz E350

Quick answers to the questions people most often search for when looking up the 2012 Mercedes-Benz E350.

• Is the 2012 Mercedes-Benz E350 fuel efficient?

  It is in line with the rest of the class. The 2012 Mercedes-Benz E350 returns 23 combined MPG, and the average car in the Midsize Cars class for the same model year sits at 25.1 MPG.
• What MPG does the 2012 Mercedes-Benz E350 get?

  The EPA rates the 2012 Mercedes-Benz E350 at 23 combined MPG, 20 MPG in city driving, and 30 MPG on the highway. Real-world numbers depend on your driving style, the weather, and how loaded the car is.
• How much does it cost to fuel a 2012 Mercedes-Benz E350 per year?

  The EPA estimates an annual fuel cost of $3,000 for the 2012 Mercedes-Benz E350. That figure assumes 15,000 miles of driving per year, a 55% city and 45% highway split, and the EPA's published average fuel price for the rated fuel grade.
• Does the 2012 Mercedes-Benz E350 require premium gas?

  Yes. The EPA lists the 2012 Mercedes-Benz E350 as requiring premium gasoline. Running it on regular can reduce performance and may affect engine warranties, so it is not a recommended way to save at the pump.
• Has the Mercedes-Benz E350 become more fuel efficient over time?

  Yes. The first EPA-rated Mercedes-Benz E350, the 2006 Mercedes-Benz E350, returned 20 combined MPG. The most recent 2026 Mercedes-Benz E350 returns 28 MPG, an improvement of 8 MPG over the run.
• How much CO₂ does the 2012 Mercedes-Benz E350 emit?

  Tailpipe CO₂ emissions are 386 g/mi. Multiplied across a typical year of driving (15,000 miles) that works out to about 5,796 kilograms of CO₂.
• What is the difference between the city and highway MPG of the 2012 Mercedes-Benz E350?

  City driving returns 20 MPG and highway driving returns 30 MPG, a gap of 10 MPG. A spread that wide is typical of cars with conventional automatic or manual transmissions, where stop-start city traffic eats more fuel than a steady highway cruise.
• What engine is in the 2012 Mercedes-Benz E350?

  The 2012 Mercedes-Benz E350 has a 3.5-liter 6-cylinder engine (EPA description: SIDI).
• What transmission and drivetrain does the 2012 Mercedes-Benz E350 have?

  The 2012 Mercedes-Benz E350 comes with a automatic 7-spd transmission and rear-wheel drive.
• How does the 2012 Mercedes-Benz E350 compare to the best car in its class?

  The most efficient car in the Midsize Cars class for the 2012 model year is the Nissan Leaf at 99 combined MPG. The Mercedes-Benz E350 returns 23 MPG, a gap of 76 MPG. If you are comparing on fuel economy alone, the class leader is worth a look.

Source: U.S. EPA fuel economy dataset. Annual fuel cost figures assume 15,000 miles of driving per year and a 55% city, 45% highway split. Real-world mileage varies with driving conditions, vehicle maintenance, fuel quality, and driver behaviour.