Mercedes-Benz E350: MPG and fuel economy by year
The EPA has rated the Mercedes-Benz E350 across 17 model years, from the 2006 Mercedes-Benz E350 through the 2026 Mercedes-Benz E350. The most recent 2026 Mercedes-Benz E350 returns 28 combined MPG. The nameplate has been in continuous production long enough to span multiple generations of EPA testing methodology.
Pick a year below to open the full Mercedes-Benz E350 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.
Fuel economy by model year
Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E350. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.
| Year | Model | Combined MPG | City | Highway | Annual fuel cost |
|---|---|---|---|---|---|
| 2026 | 2026 Mercedes-Benz E350 | 28 MPG | 25 MPG | 33 MPG | $2,450 |
| 2025 | 2025 Mercedes-Benz E350 | 28 MPG | 25 MPG | 33 MPG | $2,450 |
| 2023 | 2023 Mercedes-Benz E350 | 26 MPG | 23 MPG | 31 MPG | $2,650 |
| 2022 | 2022 Mercedes-Benz E350 | 26 MPG | 23 MPG | 31 MPG | $2,650 |
| 2021 | 2021 Mercedes-Benz E350 | 25 MPG | 22 MPG | 31 MPG | $2,750 |
| 2020 | 2020 Mercedes-Benz E350 | 26 MPG | 23 MPG | 32 MPG | $2,650 |
| 2016 | 2016 Mercedes-Benz E350 | 23 MPG | 20 MPG | 29 MPG | $3,000 |
| 2015 | 2015 Mercedes-Benz E350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2014 | 2014 Mercedes-Benz E350 | 24 MPG | 20 MPG | 30 MPG | $2,900 |
| 2013 | 2013 Mercedes-Benz E350 | 23 MPG | 19 MPG | 29 MPG | $3,000 |
| 2012 | 2012 Mercedes-Benz E350 | 23 MPG | 20 MPG | 30 MPG | $3,000 |
| 2011 | 2011 Mercedes-Benz E350 | 20 MPG | 17 MPG | 25 MPG | $3,450 |
| 2010 | 2010 Mercedes-Benz E350 | 21 MPG | 18 MPG | 26 MPG | $3,300 |
| 2009 | 2009 Mercedes-Benz E350 | 19 MPG | 17 MPG | 24 MPG | $3,650 |
| 2008 | 2008 Mercedes-Benz E350 | 19 MPG | 17 MPG | 24 MPG | $3,650 |
| 2007 | 2007 Mercedes-Benz E350 | 19 MPG | 17 MPG | 24 MPG | $3,650 |
| 2006 | 2006 Mercedes-Benz E350 | 20 MPG | 17 MPG | 25 MPG | $3,450 |
How the Mercedes-Benz E350 compares against the Midsize Cars class
Buyers usually compare the Mercedes-Benz E350 against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Cars class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.
Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.