2022 Lexus IS 350: MPG and fuel economy
The 2022 Lexus IS 350 is rated by the U.S. Environmental Protection Agency at 23 combined MPG, with 20 MPG in the city and 28 MPG on the highway. That lands well below the average for cars in the Compact Cars class in the same model year.
This page collects every fuel-economy figure the EPA publishes for the 2022 Lexus IS 350. Below you will find the headline combined, city, and highway MPG, the estimated annual fuel cost at three different driving levels, the tailpipe CO₂ emissions, and a full breakdown of the engine and drivetrain. If you want to know whether this generation got more or less efficient over the years, the year-over-year table further down covers every model year the EPA has rated.
Key takeaways
- Returns 33% worse combined MPG than the average car in the Compact Cars class for the 2022 model year (34.2 MPG class average).
- The most efficient car in the Compact Cars class for the 2022 model year is the Porsche Taycan GTS at 83 MPG.
- EPA estimates this car costs around $4,250 more in fuel over five years than an average new vehicle of the same model year.
- Requires premium gasoline, which typically adds about 40 to 60 cents per gallon to the EPA's annual fuel cost estimate.
Fuel economy at a glance
These are the EPA's official ratings for the 2022 Lexus IS 350. The numbers come from a standardised laboratory test cycle and are the same figures that appear on the window sticker of every new car. Real-world mileage varies with driving style, weather, fuel quality, and how heavily loaded the car is.
Combined MPG is a 55/45 weighted blend of the city and highway test cycles. The EPA uses it as the single number you can compare across the entire dataset, including hybrids and EVs (which use the equivalent MPGe figure).
| Combined MPG | 23 MPG |
| City MPG | 20 MPG |
| Highway MPG | 28 MPG |
| Annual fuel cost | $3,000 |
| Tailpipe CO₂ | 385 g/mi |
| Fuel type | Premium |
How the 2022 Lexus IS 350 compares
The 2022 Lexus IS 350 returns 23 combined MPG. Cars in the Compact Cars class for the same model year average 34.2 MPG, which puts this car behind the class average by about 33%.
The most efficient car in the Compact Cars class for the 2022 model year is the Porsche Taycan GTS at 83 MPG. The bar chart below puts the Lexus IS 350 alongside the class best and the class average so you can see the full picture.
For broader context, the average new car of the 2022 model year (across all classes) returns 30.7 MPG. Larger vehicles pull the all-cars average down, so do not use that figure on its own to judge a small car or a hybrid. The full list of the most efficient cars of the 2022 model year is on its own page.
Annual fuel cost across driving patterns
The headline annual fuel cost the EPA publishes assumes 15,000 miles of driving per year and a fuel mix of 55% city and 45% highway. The dollar figure is calculated using the EPA's current reference price for premium gasoline, which is $4.61/gallon. EPA updates that reference periodically rather than tracking live pump prices, so treat it as a window-sticker estimate rather than today's pump number.
The table below scales the EPA's number to three common driving patterns. The combined MPG and the reference fuel price stay constant, only the annual mileage changes. To get a current-prices estimate, take your local gas price and multiply by 652.2 gallons (the car's annual consumption at the rated MPG).
| Driving pattern | Estimated annual fuel cost |
|---|---|
| Light driver, 7,500 miles per year | $1,500 |
| Average driver, 15,000 miles per year | $3,000 |
| Heavy driver, 25,000 miles per year | $5,000 |
Year-over-year MPG for the Lexus IS 350
The EPA has rated the Lexus IS 350 across 17 model years, from 2006 Lexus IS 350 through 2026 Lexus IS 350. The numbers below are the best combined MPG figure the EPA published for each year, which lets you see when the car was at its most efficient and how recent generations stack up.
Combined MPG has stayed in roughly the same range across the run. The peak rating came with the 2018 Lexus IS 350 at 23 MPG.
| Year | Combined MPG | Open year page |
|---|---|---|
| 2026 | 22 MPG | 2026 Lexus IS 350 |
| 2025 | 23 MPG | 2025 Lexus IS 350 |
| 2024 | 23 MPG | 2024 Lexus IS 350 |
| 2023 | 23 MPG | 2023 Lexus IS 350 |
| 2022 | 23 MPG | this page |
| 2021 | 23 MPG | 2021 Lexus IS 350 |
| 2020 | 23 MPG | 2020 Lexus IS 350 |
| 2019 | 23 MPG | 2019 Lexus IS 350 |
| 2018 | 23 MPG | 2018 Lexus IS 350 |
| 2017 | 22 MPG | 2017 Lexus IS 350 |
| 2016 | 22 MPG | 2016 Lexus IS 350 |
| 2015 | 22 MPG | 2015 Lexus IS 350 |
| 2014 | 22 MPG | 2014 Lexus IS 350 |
| 2009 | 20 MPG | 2009 Lexus IS 350 |
| 2008 | 20 MPG | 2008 Lexus IS 350 |
| 2007 | 21 MPG | 2007 Lexus IS 350 |
| 2006 | 21 MPG | 2006 Lexus IS 350 |
Compare against other Compact Cars for 2022
If you are cross-shopping the 2022 Lexus IS 350, the most useful comparison is against the other cars in the Compact Cars class for the same model year. The list below shows the highest-MPG peers, ranked from most to least efficient. Click any of them to open its full page.
The Porsche Taycan GTS leads this group at 83 MPG, 60 MPG ahead of the 2022 Lexus IS 350.
Specifications
The 2022 Lexus IS 350 runs a 3.5-liter 6-cylinder engine paired with a automatic (s8), sending power through rear-wheel drive.
Engine, transmission, and drivetrain together drive most of the variation in fuel economy across trims. A larger engine moves the car with less effort but burns more fuel. A turbo lets a small engine punch above its weight, often without much MPG penalty. All-wheel drive adds traction and weight, and usually costs a couple of MPG compared with two-wheel drive of the same engine.
- Vehicle class
- Compact Cars
- Engine
- 3.5L 6-cylinder
- Transmission
- Automatic (S8)
- Drivetrain
- Rear-Wheel Drive
- Fuel type
- Premium
- Annual petroleum use
- 12.9 barrels per year
Common questions about the 2022 Lexus IS 350
Quick answers to the questions people most often search for when looking up the 2022 Lexus IS 350.
-
Is the 2022 Lexus IS 350 fuel efficient?
Not particularly. The 2022 Lexus IS 350 returns 23 combined MPG, which trails the average car in the Compact Cars class for the same model year by about 33%. -
What MPG does the 2022 Lexus IS 350 get?
The EPA rates the 2022 Lexus IS 350 at 23 combined MPG, 20 MPG in city driving, and 28 MPG on the highway. Real-world numbers depend on your driving style, the weather, and how loaded the car is. -
How much does it cost to fuel a 2022 Lexus IS 350 per year?
The EPA estimates an annual fuel cost of $3,000 for the 2022 Lexus IS 350. That figure assumes 15,000 miles of driving per year, a 55% city and 45% highway split, and the EPA's published average fuel price for the rated fuel grade. -
Does the 2022 Lexus IS 350 require premium gas?
Yes. The EPA lists the 2022 Lexus IS 350 as requiring premium gasoline. Running it on regular can reduce performance and may affect engine warranties, so it is not a recommended way to save at the pump. -
Has the Lexus IS 350 become more fuel efficient over time?
Combined MPG has stayed close to flat across the run. Both the earliest (2006 Lexus IS 350, 21 MPG) and most recent (2026 Lexus IS 350, 22 MPG) versions sit in the same range. -
How much CO₂ does the 2022 Lexus IS 350 emit?
Tailpipe CO₂ emissions are 385 g/mi. Multiplied across a typical year of driving (15,000 miles) that works out to about 5,775 kilograms of CO₂. -
What is the difference between the city and highway MPG of the 2022 Lexus IS 350?
City driving returns 20 MPG and highway driving returns 28 MPG, a gap of 8 MPG. A spread that wide is typical of cars with conventional automatic or manual transmissions, where stop-start city traffic eats more fuel than a steady highway cruise. -
What engine is in the 2022 Lexus IS 350?
The 2022 Lexus IS 350 has a 3.5-liter 6-cylinder engine (EPA description: SIDI & PFI). -
What transmission and drivetrain does the 2022 Lexus IS 350 have?
The 2022 Lexus IS 350 comes with a automatic (s8) transmission and rear-wheel drive. -
How does the 2022 Lexus IS 350 compare to the best car in its class?
The most efficient car in the Compact Cars class for the 2022 model year is the Porsche Taycan GTS at 83 combined MPG. The Lexus IS 350 returns 23 MPG, a gap of 60 MPG. If you are comparing on fuel economy alone, the class leader is worth a look.
Source: U.S. EPA fuel economy dataset. Annual fuel cost figures assume 15,000 miles of driving per year and a 55% city, 45% highway split. Real-world mileage varies with driving conditions, vehicle maintenance, fuel quality, and driver behaviour.