Lexus IS 350: MPG and fuel economy by year
The EPA has rated the Lexus IS 350 across 17 model years, from the 2006 Lexus IS 350 through the 2026 Lexus IS 350. The most recent 2026 Lexus IS 350 returns 22 combined MPG. The most efficient model year was the 2025 Lexus IS 350 at 23 MPG. The nameplate has been in continuous production long enough to span multiple generations of EPA testing methodology.
Pick a year below to open the full Lexus IS 350 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.
Fuel economy by model year
Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Lexus IS 350. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.
| Year | Model | Combined MPG | City | Highway | Annual fuel cost |
|---|---|---|---|---|---|
| 2026 | 2026 Lexus IS 350 | 22 MPG | 19 MPG | 27 MPG | $3,150 |
| 2025 | 2025 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2024 | 2024 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2023 | 2023 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2022 | 2022 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2021 | 2021 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2020 | 2020 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2019 | 2019 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2018 | 2018 Lexus IS 350 | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2017 | 2017 Lexus IS 350 | 22 MPG | 19 MPG | 28 MPG | $3,150 |
| 2016 | 2016 Lexus IS 350 | 22 MPG | 19 MPG | 28 MPG | $3,150 |
| 2015 | 2015 Lexus IS 350 | 22 MPG | 19 MPG | 28 MPG | $3,150 |
| 2014 | 2014 Lexus IS 350 | 22 MPG | 19 MPG | 28 MPG | $3,150 |
| 2009 | 2009 Lexus IS 350 | 20 MPG | 18 MPG | 25 MPG | $3,450 |
| 2008 | 2008 Lexus IS 350 | 20 MPG | 18 MPG | 25 MPG | $3,450 |
| 2007 | 2007 Lexus IS 350 | 21 MPG | 19 MPG | 25 MPG | $3,300 |
| 2006 | 2006 Lexus IS 350 | 21 MPG | 19 MPG | 26 MPG | $3,300 |
How the Lexus IS 350 compares against the Compact Cars class
Buyers usually compare the Lexus IS 350 against other cars in the same EPA class. The list below shows the most efficient cars in the Compact Cars class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.
Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.