2022 Mercedes-Benz S500 4matic: MPG and fuel economy
The 2022 Mercedes-Benz S500 4matic is a hybrid rated at 24 combined MPG by the U.S. Environmental Protection Agency. It returns 21 MPG in the city and 30 MPG on the highway.
This page collects every fuel-economy figure the EPA publishes for the 2022 Mercedes-Benz S500 4matic. Below you will find the headline combined, city, and highway MPG, the estimated annual fuel cost at three different driving levels, the tailpipe CO₂ emissions, and a full breakdown of the engine and drivetrain. If you want to know whether this generation got more or less efficient over the years, the year-over-year table further down covers every model year the EPA has rated.
Key takeaways
- Returns 42% worse combined MPG than the average car in the Large Cars class for the 2022 model year (41.1 MPG class average).
- The most efficient car in the Large Cars class for the 2022 model year is the Lucid Air G Touring AWD w/19 inch wheels at 131 MPG.
- The Mercedes-Benz S500 4matic has gained 7 MPG since its first rated model year, the 2003 Mercedes-Benz S500 4matic at 16 MPG.
- EPA estimates this car costs around $3,750 more in fuel over five years than an average new vehicle of the same model year.
- Requires premium gasoline, which typically adds about 40 to 60 cents per gallon to the EPA's annual fuel cost estimate.
Fuel economy at a glance
These are the EPA's official ratings for the 2022 Mercedes-Benz S500 4matic. The numbers come from a standardised laboratory test cycle and are the same figures that appear on the window sticker of every new car. Real-world mileage varies with driving style, weather, fuel quality, and how heavily loaded the car is.
Combined MPG is a 55/45 weighted blend of the city and highway test cycles. The EPA uses it as the single number you can compare across the entire dataset, including hybrids and EVs (which use the equivalent MPGe figure).
| Combined MPG | 24 MPG |
| City MPG | 21 MPG |
| Highway MPG | 30 MPG |
| Annual fuel cost | $2,900 |
| Tailpipe CO₂ | 372 g/mi |
| Fuel type | Premium |
How the 2022 Mercedes-Benz S500 4matic compares
The 2022 Mercedes-Benz S500 4matic returns 24 combined MPG. Cars in the Large Cars class for the same model year average 41.1 MPG, which puts this car behind the class average by about 42%.
The most efficient car in the Large Cars class for the 2022 model year is the Lucid Air G Touring AWD w/19 inch wheels at 131 MPG. The bar chart below puts the Mercedes-Benz S500 4matic alongside the class best and the class average so you can see the full picture.
For broader context, the average new car of the 2022 model year (across all classes) returns 30.7 MPG. Larger vehicles pull the all-cars average down, so do not use that figure on its own to judge a small car or a hybrid. The full list of the most efficient cars of the 2022 model year is on its own page.
Annual fuel cost across driving patterns
The headline annual fuel cost the EPA publishes assumes 15,000 miles of driving per year and a fuel mix of 55% city and 45% highway. The dollar figure is calculated using the EPA's current reference price for premium gasoline, which is $4.61/gallon. EPA updates that reference periodically rather than tracking live pump prices, so treat it as a window-sticker estimate rather than today's pump number.
The table below scales the EPA's number to three common driving patterns. The combined MPG and the reference fuel price stay constant, only the annual mileage changes. To get a current-prices estimate, take your local gas price and multiply by 625 gallons (the car's annual consumption at the rated MPG).
| Driving pattern | Estimated annual fuel cost |
|---|---|
| Light driver, 7,500 miles per year | $1,450 |
| Average driver, 15,000 miles per year | $2,900 |
| Heavy driver, 25,000 miles per year | $4,833 |
Year-over-year MPG for the Mercedes-Benz S500 4matic
The EPA has rated the Mercedes-Benz S500 4matic across 10 model years, from 2003 Mercedes-Benz S500 4matic through 2026 Mercedes-Benz S500 4matic. The numbers below are the best combined MPG figure the EPA published for each year, which lets you see when the car was at its most efficient and how recent generations stack up.
The 2003 Mercedes-Benz S500 4matic returned 16 MPG. The most recent 2026 Mercedes-Benz S500 4matic returns 23 MPG. That is an improvement of 7 MPG over 23 model years, the kind of gain that usually comes from smaller engines, hybrid systems, or aerodynamic redesigns.
| Year | Combined MPG | Open year page |
|---|---|---|
| 2026 | 23 MPG | 2026 Mercedes-Benz S500 4matic |
| 2025 | 24 MPG | 2025 Mercedes-Benz S500 4matic |
| 2024 | 24 MPG | 2024 Mercedes-Benz S500 4matic |
| 2023 | 23 MPG | 2023 Mercedes-Benz S500 4matic |
| 2022 | 24 MPG | this page |
| 2021 | 24 MPG | 2021 Mercedes-Benz S500 4matic |
| 2006 | 16 MPG | 2006 Mercedes-Benz S500 4matic |
| 2005 | 16 MPG | 2005 Mercedes-Benz S500 4matic |
| 2004 | 16 MPG | 2004 Mercedes-Benz S500 4matic |
| 2003 | 16 MPG | 2003 Mercedes-Benz S500 4matic |
Compare against other Large Cars for 2022
If you are cross-shopping the 2022 Mercedes-Benz S500 4matic, the most useful comparison is against the other cars in the Large Cars class for the same model year. The list below shows the highest-MPG peers, ranked from most to least efficient. Click any of them to open its full page.
The Lucid Air G Touring AWD w/19 inch wheels leads this group at 131 MPG, 107 MPG ahead of the 2022 Mercedes-Benz S500 4matic.
Specifications
The 2022 Mercedes-Benz S500 4matic runs a 3-liter 6-cylinder engine paired with a automatic 9-spd, sending power through all-wheel drive.
Engine, transmission, and drivetrain together drive most of the variation in fuel economy across trims. A larger engine moves the car with less effort but burns more fuel. A turbo lets a small engine punch above its weight, often without much MPG penalty. All-wheel drive adds traction and weight, and usually costs a couple of MPG compared with two-wheel drive of the same engine.
- Vehicle class
- Large Cars
- Engine
- 3L 6-cylinder
- Transmission
- Automatic 9-spd
- Drivetrain
- All-Wheel Drive
- Fuel type
- Premium
- Annual petroleum use
- 12.4 barrels per year
- Start-stop system
- Yes
Common questions about the 2022 Mercedes-Benz S500 4matic
Quick answers to the questions people most often search for when looking up the 2022 Mercedes-Benz S500 4matic.
-
Is the 2022 Mercedes-Benz S500 4matic fuel efficient?
Not particularly. The 2022 Mercedes-Benz S500 4matic returns 24 combined MPG, which trails the average car in the Large Cars class for the same model year by about 42%. -
What MPG does the 2022 Mercedes-Benz S500 4matic get?
The EPA rates the 2022 Mercedes-Benz S500 4matic at 24 combined MPG, 21 MPG in city driving, and 30 MPG on the highway. Real-world numbers depend on your driving style, the weather, and how loaded the car is. -
How much does it cost to fuel a 2022 Mercedes-Benz S500 4matic per year?
The EPA estimates an annual fuel cost of $2,900 for the 2022 Mercedes-Benz S500 4matic. That figure assumes 15,000 miles of driving per year, a 55% city and 45% highway split, and the EPA's published average fuel price for the rated fuel grade. -
Does the 2022 Mercedes-Benz S500 4matic require premium gas?
Yes. The EPA lists the 2022 Mercedes-Benz S500 4matic as requiring premium gasoline. Running it on regular can reduce performance and may affect engine warranties, so it is not a recommended way to save at the pump. -
Has the Mercedes-Benz S500 4matic become more fuel efficient over time?
Yes. The first EPA-rated Mercedes-Benz S500 4matic, the 2003 Mercedes-Benz S500 4matic, returned 16 combined MPG. The most recent 2026 Mercedes-Benz S500 4matic returns 23 MPG, an improvement of 7 MPG over the run. -
How much CO₂ does the 2022 Mercedes-Benz S500 4matic emit?
Tailpipe CO₂ emissions are 372 g/mi. Multiplied across a typical year of driving (15,000 miles) that works out to about 5,580 kilograms of CO₂. -
What is the difference between the city and highway MPG of the 2022 Mercedes-Benz S500 4matic?
City driving returns 21 MPG and highway driving returns 30 MPG, a gap of 9 MPG. A spread that wide is typical of cars with conventional automatic or manual transmissions, where stop-start city traffic eats more fuel than a steady highway cruise. -
What engine is in the 2022 Mercedes-Benz S500 4matic?
The 2022 Mercedes-Benz S500 4matic has a 3-liter 6-cylinder engine (EPA description: SIDI; Mild Hybrid). -
What transmission and drivetrain does the 2022 Mercedes-Benz S500 4matic have?
The 2022 Mercedes-Benz S500 4matic comes with a automatic 9-spd transmission and all-wheel drive. All-wheel-drive variants typically read 1 to 3 MPG lower than the front-wheel-drive equivalent of the same engine, since the extra hardware adds weight and parasitic loss. -
How does the 2022 Mercedes-Benz S500 4matic compare to the best car in its class?
The most efficient car in the Large Cars class for the 2022 model year is the Lucid Air G Touring AWD w/19 inch wheels at 131 combined MPG. The Mercedes-Benz S500 4matic returns 24 MPG, a gap of 107 MPG. If you are comparing on fuel economy alone, the class leader is worth a look.
Source: U.S. EPA fuel economy dataset. Annual fuel cost figures assume 15,000 miles of driving per year and a 55% city, 45% highway split. Real-world mileage varies with driving conditions, vehicle maintenance, fuel quality, and driver behaviour.