Pick a year below to open the full Mercedes-Benz C300 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz C300. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2026 2026 Mercedes-Benz C300 29 MPG 25 MPG 35 MPG $2,400
2025 2025 Mercedes-Benz C300 29 MPG 25 MPG 35 MPG $2,400
2024 2024 Mercedes-Benz C300 30 MPG 26 MPG 36 MPG $2,300
2023 2023 Mercedes-Benz C300 29 MPG 25 MPG 36 MPG $2,400
2022 2022 Mercedes-Benz C300 29 MPG 25 MPG 35 MPG $2,400
2021 2021 Mercedes-Benz C300 27 MPG 23 MPG 35 MPG $2,550
2020 2020 Mercedes-Benz C300 28 MPG 24 MPG 35 MPG $2,450
2019 2019 Mercedes-Benz C300 27 MPG 23 MPG 34 MPG $2,550
2018 2018 Mercedes-Benz C300 27 MPG 24 MPG 33 MPG $2,550
2017 2017 Mercedes-Benz C300 28 MPG 24 MPG 34 MPG $2,450
2016 2016 Mercedes-Benz C300 28 MPG 25 MPG 34 MPG $2,450
2015 2015 Mercedes-Benz C300 28 MPG 25 MPG 33 MPG $2,450
2011 2011 Mercedes-Benz C300 21 MPG 18 MPG 25 MPG $3,300
2010 2010 Mercedes-Benz C300 21 MPG 18 MPG 26 MPG $3,300
2009 2009 Mercedes-Benz C300 21 MPG 18 MPG 25 MPG $3,300
2008 2008 Mercedes-Benz C300 21 MPG 18 MPG 26 MPG $3,300

How the Mercedes-Benz C300 compares against the Compact Cars class

Buyers usually compare the Mercedes-Benz C300 against other cars in the same EPA class. The list below shows the most efficient cars in the Compact Cars class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.