2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon): MPG and fuel economy

This page collects every fuel-economy figure the EPA publishes for the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon). Below you will find the headline combined, city, and highway MPG, the estimated annual fuel cost at three different driving levels, the tailpipe CO₂ emissions, and a full breakdown of the engine and drivetrain.

Fuel economy at a glance

These are the EPA's official ratings for the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon). The numbers come from a standardised laboratory test cycle and are the same figures that appear on the window sticker of every new car. Real-world mileage varies with driving style, weather, fuel quality, and how heavily loaded the car is.

Combined MPG is a 55/45 weighted blend of the city and highway test cycles. The EPA uses it as the single number you can compare across the entire dataset, including hybrids and EVs (which use the equivalent MPGe figure).

How the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) compares

The 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) returns 22 combined MPG. Cars in the Midsize Station Wagons class for the same model year average 38.7 MPG, which puts this car behind the class average by about 43%.

The most efficient car in the Midsize Station Wagons class for the 2026 model year is the Mercedes-Benz EQE 320 Plus (SUV) at 93 MPG. The bar chart below puts the Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) alongside the class best and the class average so you can see the full picture.

For broader context, the average new car of the 2026 model year (across all classes) returns 45.5 MPG. Larger vehicles pull the all-cars average down, so do not use that figure on its own to judge a small car or a hybrid. The full list of the most efficient cars of the 2026 model year is on its own page.

Annual fuel cost across driving patterns

The headline annual fuel cost the EPA publishes assumes 15,000 miles of driving per year and a fuel mix of 55% city and 45% highway. The dollar figure is calculated using the EPA's current reference price for premium gasoline, which is $4.61/gallon. EPA updates that reference periodically rather than tracking live pump prices, so treat it as a window-sticker estimate rather than today's pump number.

The table below scales the EPA's number to three common driving patterns. The combined MPG and the reference fuel price stay constant, only the annual mileage changes. To get a current-prices estimate, take your local gas price and multiply by 681.8 gallons (the car's annual consumption at the rated MPG).

Compare against other Midsize Station Wagons for 2026

If you are cross-shopping the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon), the most useful comparison is against the other cars in the Midsize Station Wagons class for the same model year. The list below shows the highest-MPG peers, ranked from most to least efficient. Click any of them to open its full page.

The Mercedes-Benz EQE 320 Plus (SUV) leads this group at 93 MPG, 71 MPG ahead of the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon).

Specifications

The 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) runs a 3-liter 6-cylinder turbocharged engine paired with a automatic 9-spd, sending power through all-wheel drive.

Engine, transmission, and drivetrain together drive most of the variation in fuel economy across trims. A larger engine moves the car with less effort but burns more fuel. A turbo lets a small engine punch above its weight, often without much MPG penalty. All-wheel drive adds traction and weight, and usually costs a couple of MPG compared with two-wheel drive of the same engine.

Vehicle class

Midsize Station Wagons

Engine

3L 6-cylinder turbocharged

Transmission

Automatic 9-spd

Drivetrain

All-Wheel Drive

Fuel type

Premium and Electricity

Annual petroleum use

4.2 barrels per year

Common questions about the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon)

Quick answers to the questions people most often search for when looking up the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon).

• Is the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) fuel efficient?

  Not particularly. The 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) returns 22 combined MPG, which trails the average car in the Midsize Station Wagons class for the same model year by about 43%.
• What MPG does the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) get?

  The EPA rates the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) at 22 combined MPG, 21 MPG in city driving, and 25 MPG on the highway. Real-world numbers depend on your driving style, the weather, and how loaded the car is.
• How much does it cost to fuel a 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) per year?

  The EPA estimates an annual fuel cost of $3,150 for the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon). That figure assumes 15,000 miles of driving per year, a 55% city and 45% highway split, and the EPA's published average fuel price for the rated fuel grade.
• Does the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) require premium gas?

  Yes. The EPA lists the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) as requiring premium gasoline. Running it on regular can reduce performance and may affect engine warranties, so it is not a recommended way to save at the pump.
• How much CO₂ does the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) emit?

  Tailpipe CO₂ emissions are 127 g/mi. Multiplied across a typical year of driving (15,000 miles) that works out to about 1,905 kilograms of CO₂.
• What is the difference between the city and highway MPG of the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon)?

  City driving returns 21 MPG and highway driving returns 25 MPG, a gap of 4 MPG. The two figures are close enough that the car will hold its rated efficiency well across most driving patterns.
• What engine is in the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon)?

  The 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) has a 3-liter 6-cylinder turbocharged engine (EPA description: SIDI; PHEV).
• What transmission and drivetrain does the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) have?

  The 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) comes with a automatic 9-spd transmission and all-wheel drive. All-wheel-drive variants typically read 1 to 3 MPG lower than the front-wheel-drive equivalent of the same engine, since the extra hardware adds weight and parasitic loss.
• How does the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) compare to the best car in its class?

  The most efficient car in the Midsize Station Wagons class for the 2026 model year is the Mercedes-Benz EQE 320 Plus (SUV) at 93 combined MPG. The Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) returns 22 MPG, a gap of 71 MPG. If you are comparing on fuel economy alone, the class leader is worth a look.
• How much does the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) save on fuel compared to an average car?

  The EPA estimates that over five years, the 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) will save you about $1,250 in fuel compared with an average new vehicle of the same model year. That figure uses the same 15,000 mile per year and EPA fuel-price assumption as the annual fuel cost.

Source: U.S. EPA fuel economy dataset. Annual fuel cost figures assume 15,000 miles of driving per year and a 55% city, 45% highway split. Real-world mileage varies with driving conditions, vehicle maintenance, fuel quality, and driver behaviour.