Pick a year below to open the full Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon). Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2026 2026 Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) 22 MPG 21 MPG 25 MPG $3,150

How the Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) compares against the Midsize Station Wagons class

Buyers usually compare the Mercedes-Benz AMG E53 Hybrid 4matic Plus (station wagon) against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Station Wagons class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.