Pick a year below to open the full Lexus RX 350 2WD page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Lexus RX 350 2WD. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2011 2011 Lexus RX 350 2WD 21 MPG 18 MPG 24 MPG $3,300
2010 2010 Lexus RX 350 2WD 21 MPG 18 MPG 25 MPG $3,300
2009 2009 Lexus RX 350 2WD 20 MPG 18 MPG 23 MPG $3,450
2008 2008 Lexus RX 350 2WD 20 MPG 18 MPG 23 MPG $3,450
2007 2007 Lexus RX 350 2WD 20 MPG 18 MPG 23 MPG $3,450

How the Lexus RX 350 2WD compares against the Sport Utility Vehicle - 2WD class

Buyers usually compare the Lexus RX 350 2WD against other cars in the same EPA class. The list below shows the most efficient cars in the Sport Utility Vehicle - 2WD class for the 2011 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.