Pick a year below to open the full Lexus NX 250 AWD page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Lexus NX 250 AWD. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2025 2025 Lexus NX 250 AWD 28 MPG 25 MPG 32 MPG $2,150
2024 2024 Lexus NX 250 AWD 28 MPG 25 MPG 32 MPG $2,150
2023 2023 Lexus NX 250 AWD 28 MPG 25 MPG 32 MPG $2,150
2022 2022 Lexus NX 250 AWD 28 MPG 25 MPG 32 MPG $2,150

How the Lexus NX 250 AWD compares against the Small Sport Utility Vehicle 4WD class

Buyers usually compare the Lexus NX 250 AWD against other cars in the same EPA class. The list below shows the most efficient cars in the Small Sport Utility Vehicle 4WD class for the 2025 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.