Lexus NX 250: MPG and fuel economy by year

The EPA has rated the Lexus NX 250 across 4 model years, from the 2022 Lexus NX 250 through the 2025 Lexus NX 250. The most recent 2025 Lexus NX 250 returns 28 combined MPG.

Pick a year below to open the full Lexus NX 250 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Lexus NX 250. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year	Model	Combined MPG	City	Highway	Annual fuel cost
2025	2025 Lexus NX 250	28 MPG	26 MPG	33 MPG	$2,150
2024	2024 Lexus NX 250	28 MPG	26 MPG	33 MPG	$2,150
2023	2023 Lexus NX 250	28 MPG	26 MPG	33 MPG	$2,150
2022	2022 Lexus NX 250	28 MPG	26 MPG	33 MPG	$2,150

How the Lexus NX 250 compares against the Small Sport Utility Vehicle 2WD class

Buyers usually compare the Lexus NX 250 against other cars in the same EPA class. The list below shows the most efficient cars in the Small Sport Utility Vehicle 2WD class for the 2025 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.