Pick a year below to open the full Lexus LS 500 AWD page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Lexus LS 500 AWD. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2026 2026 Lexus LS 500 AWD 21 MPG 17 MPG 27 MPG $3,300
2025 2025 Lexus LS 500 AWD 21 MPG 17 MPG 27 MPG $3,300
2024 2024 Lexus LS 500 AWD 21 MPG 17 MPG 27 MPG $3,300
2023 2023 Lexus LS 500 AWD 21 MPG 17 MPG 27 MPG $3,300
2022 2022 Lexus LS 500 AWD 21 MPG 17 MPG 27 MPG $3,300
2021 2021 Lexus LS 500 AWD 21 MPG 17 MPG 27 MPG $3,300
2020 2020 Lexus LS 500 AWD 21 MPG 18 MPG 27 MPG $3,300
2019 2019 Lexus LS 500 AWD 21 MPG 18 MPG 27 MPG $3,300
2018 2018 Lexus LS 500 AWD 21 MPG 18 MPG 27 MPG $3,300

How the Lexus LS 500 AWD compares against the Midsize Cars class

Buyers usually compare the Lexus LS 500 AWD against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Cars class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.