Lexus IS 500: MPG and fuel economy by year
The EPA has rated the Lexus IS 500 across 4 model years, from the 2022 Lexus IS 500 through the 2025 Lexus IS 500. The most recent 2025 Lexus IS 500 returns 20 combined MPG.
Pick a year below to open the full Lexus IS 500 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.
Fuel economy by model year
Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Lexus IS 500. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.
| Year | Model | Combined MPG | City | Highway | Annual fuel cost |
|---|---|---|---|---|---|
| 2025 | 2025 Lexus IS 500 | 20 MPG | 17 MPG | 25 MPG | $3,450 |
| 2024 | 2024 Lexus IS 500 | 20 MPG | 17 MPG | 25 MPG | $3,450 |
| 2023 | 2023 Lexus IS 500 | 20 MPG | 17 MPG | 25 MPG | $3,450 |
| 2022 | 2022 Lexus IS 500 | 20 MPG | 17 MPG | 25 MPG | $3,450 |
How the Lexus IS 500 compares against the Compact Cars class
Buyers usually compare the Lexus IS 500 against other cars in the same EPA class. The list below shows the most efficient cars in the Compact Cars class for the 2025 model year, the latest year on this page. Each link opens the full page for that car.
Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.