2025 Mercedes-Benz S580 4matic Maybach: MPG and fuel economy

This page collects every fuel-economy figure the EPA publishes for the 2025 Mercedes-Benz S580 4matic Maybach. Below you will find the headline combined, city, and highway MPG, the estimated annual fuel cost at three different driving levels, the tailpipe CO₂ emissions, and a full breakdown of the engine and drivetrain. If you want to know whether this generation got more or less efficient over the years, the year-over-year table further down covers every model year the EPA has rated.

Fuel economy at a glance

These are the EPA's official ratings for the 2025 Mercedes-Benz S580 4matic Maybach. The numbers come from a standardised laboratory test cycle and are the same figures that appear on the window sticker of every new car. Real-world mileage varies with driving style, weather, fuel quality, and how heavily loaded the car is.

Combined MPG is a 55/45 weighted blend of the city and highway test cycles. The EPA uses it as the single number you can compare across the entire dataset, including hybrids and EVs (which use the equivalent MPGe figure).

How the 2025 Mercedes-Benz S580 4matic Maybach compares

The 2025 Mercedes-Benz S580 4matic Maybach returns 20 combined MPG. Cars in the Large Cars class for the same model year average 59.5 MPG, which puts this car behind the class average by about 66%.

The most efficient car in the Large Cars class for the 2025 model year is the Lucid Air Pure RWD with 19 inch wheels at 146 MPG. The bar chart below puts the Mercedes-Benz S580 4matic Maybach alongside the class best and the class average so you can see the full picture.

For broader context, the average new car of the 2025 model year (across all classes) returns 44.3 MPG. Larger vehicles pull the all-cars average down, so do not use that figure on its own to judge a small car or a hybrid. The full list of the most efficient cars of the 2025 model year is on its own page.

Annual fuel cost across driving patterns

The headline annual fuel cost the EPA publishes assumes 15,000 miles of driving per year and a fuel mix of 55% city and 45% highway. The dollar figure is calculated using the EPA's current reference price for premium gasoline, which is $4.61/gallon. EPA updates that reference periodically rather than tracking live pump prices, so treat it as a window-sticker estimate rather than today's pump number.

The table below scales the EPA's number to three common driving patterns. The combined MPG and the reference fuel price stay constant, only the annual mileage changes. To get a current-prices estimate, take your local gas price and multiply by 750 gallons (the car's annual consumption at the rated MPG).

Year-over-year MPG for the Mercedes-Benz S580 4matic Maybach

The EPA has rated the Mercedes-Benz S580 4matic Maybach across 6 model years, from 2021 Mercedes-Benz S580 4matic Maybach through 2026 Mercedes-Benz S580 4matic Maybach. The numbers below are the best combined MPG figure the EPA published for each year, which lets you see when the car was at its most efficient and how recent generations stack up.

Combined MPG has stayed in roughly the same range across the run. The peak rating came with the 2024 Mercedes-Benz S580 4matic Maybach at 21 MPG.

Compare against other Large Cars for 2025

If you are cross-shopping the 2025 Mercedes-Benz S580 4matic Maybach, the most useful comparison is against the other cars in the Large Cars class for the same model year. The list below shows the highest-MPG peers, ranked from most to least efficient. Click any of them to open its full page.

The Lucid Air Pure RWD with 19 inch wheels leads this group at 146 MPG, 126 MPG ahead of the 2025 Mercedes-Benz S580 4matic Maybach.

Specifications

The 2025 Mercedes-Benz S580 4matic Maybach runs a 4-liter 8-cylinder turbocharged engine paired with a automatic 9-spd, sending power through all-wheel drive.

Engine, transmission, and drivetrain together drive most of the variation in fuel economy across trims. A larger engine moves the car with less effort but burns more fuel. A turbo lets a small engine punch above its weight, often without much MPG penalty. All-wheel drive adds traction and weight, and usually costs a couple of MPG compared with two-wheel drive of the same engine.

Vehicle class

Large Cars

Engine

4L 8-cylinder turbocharged

Transmission

Automatic 9-spd

Drivetrain

All-Wheel Drive

Fuel type

Premium

Annual petroleum use

14.9 barrels per year

Start-stop system

Yes

Common questions about the 2025 Mercedes-Benz S580 4matic Maybach

Quick answers to the questions people most often search for when looking up the 2025 Mercedes-Benz S580 4matic Maybach.

• Is the 2025 Mercedes-Benz S580 4matic Maybach fuel efficient?

  Not particularly. The 2025 Mercedes-Benz S580 4matic Maybach returns 20 combined MPG, which trails the average car in the Large Cars class for the same model year by about 66%.
• What MPG does the 2025 Mercedes-Benz S580 4matic Maybach get?

  The EPA rates the 2025 Mercedes-Benz S580 4matic Maybach at 20 combined MPG, 16 MPG in city driving, and 27 MPG on the highway. Real-world numbers depend on your driving style, the weather, and how loaded the car is.
• How much does it cost to fuel a 2025 Mercedes-Benz S580 4matic Maybach per year?

  The EPA estimates an annual fuel cost of $3,450 for the 2025 Mercedes-Benz S580 4matic Maybach. That figure assumes 15,000 miles of driving per year, a 55% city and 45% highway split, and the EPA's published average fuel price for the rated fuel grade.
• Does the 2025 Mercedes-Benz S580 4matic Maybach require premium gas?

  Yes. The EPA lists the 2025 Mercedes-Benz S580 4matic Maybach as requiring premium gasoline. Running it on regular can reduce performance and may affect engine warranties, so it is not a recommended way to save at the pump.
• Has the Mercedes-Benz S580 4matic Maybach become more fuel efficient over time?

  Combined MPG has stayed close to flat across the run. Both the earliest (2021 Mercedes-Benz S580 4matic Maybach, 19 MPG) and most recent (2026 Mercedes-Benz S580 4matic Maybach, 20 MPG) versions sit in the same range.
• How much CO₂ does the 2025 Mercedes-Benz S580 4matic Maybach emit?

  Tailpipe CO₂ emissions are 451 g/mi. Multiplied across a typical year of driving (15,000 miles) that works out to about 6,765 kilograms of CO₂.
• What is the difference between the city and highway MPG of the 2025 Mercedes-Benz S580 4matic Maybach?

  City driving returns 16 MPG and highway driving returns 27 MPG, a gap of 11 MPG. A spread that wide is typical of cars with conventional automatic or manual transmissions, where stop-start city traffic eats more fuel than a steady highway cruise.
• What engine is in the 2025 Mercedes-Benz S580 4matic Maybach?

  The 2025 Mercedes-Benz S580 4matic Maybach has a 4-liter 8-cylinder turbocharged engine (EPA description: SIDI; Mild Hybrid).
• What transmission and drivetrain does the 2025 Mercedes-Benz S580 4matic Maybach have?

  The 2025 Mercedes-Benz S580 4matic Maybach comes with a automatic 9-spd transmission and all-wheel drive. All-wheel-drive variants typically read 1 to 3 MPG lower than the front-wheel-drive equivalent of the same engine, since the extra hardware adds weight and parasitic loss.
• How does the 2025 Mercedes-Benz S580 4matic Maybach compare to the best car in its class?

  The most efficient car in the Large Cars class for the 2025 model year is the Lucid Air Pure RWD with 19 inch wheels at 146 combined MPG. The Mercedes-Benz S580 4matic Maybach returns 20 MPG, a gap of 126 MPG. If you are comparing on fuel economy alone, the class leader is worth a look.

Source: U.S. EPA fuel economy dataset. Annual fuel cost figures assume 15,000 miles of driving per year and a 55% city, 45% highway split. Real-world mileage varies with driving conditions, vehicle maintenance, fuel quality, and driver behaviour.