Mercedes-Benz S450 4matic MPG and Fuel Economy

Mercedes-Benz have been manufacturing models of S450 4matic for 3 years, with the latest vehicle in 2020 having a combined MPG of 22.

The estimated fuel cost for the 2020 Mercedes-Benz S450 4matic is $3,350 per year.

Government regulators have estimated that value based on 15,000 miles driven per year, using regular gasoline, and a split of 55% city driving and 45% highway driving.

💵 Compared to an average vehicle over 5 years, you will spend $5,250 more on fuel driving a 2020 Mercedes-Benz S450 4matic.

🛢 The Mercedes-Benz S450 4matic will consume roughly 14 barrels of petroleum per year, using the standard estimate of 15,000 miles per year.

💨 For every mile driven, the Mercedes-Benz S450 4matic will emit 408 grams of CO2, which is about 6,120,000 grams of CO2 per year.

🌳 To help you understand the impact of this, a normal tree will absorb around 21,000 grams of CO2 per year. This means that roughly 292 trees would be needed to offset emissions from the Mercedes-Benz S450 4matic.

The table below is a complete list of the 3 Mercedes-Benz S450 4matic fuel efficiency specifications we have data for.

Click any vehicle link to see a more detailed breakdown of the car, miles per gallon, emissions, and more.

Link To or Reference This Page

If you use this page in your research, please reference MPG Buddy as the source.

  • "Mercedes-Benz S450 4matic MPG and Fuel Economy." MPG Buddy. Accessed on January 3, 2026. https://mpgbuddy.com/cars/mercedes-benz/s450-4matic.

  • "Mercedes-Benz S450 4matic MPG and Fuel Economy." MPG Buddy, https://mpgbuddy.com/cars/mercedes-benz/s450-4matic. Accessed January 3, 2026.

  • Mercedes-Benz S450 4matic MPG and Fuel Economy. MPG Buddy. Retrieved from https://mpgbuddy.com/cars/mercedes-benz/s450-4matic.