Mercedes-Benz S450 4matic: MPG and fuel economy by year

The EPA has rated the Mercedes-Benz S450 4matic across 3 model years, from the 2018 Mercedes-Benz S450 4matic through the 2020 Mercedes-Benz S450 4matic. The most recent 2020 Mercedes-Benz S450 4matic returns 22 combined MPG.

Pick a year below to open the full Mercedes-Benz S450 4matic page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz S450 4matic. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year	Model	Combined MPG	City	Highway	Annual fuel cost
2020	2020 Mercedes-Benz S450 4matic	22 MPG	18 MPG	28 MPG	$3,150
2019	2019 Mercedes-Benz S450 4matic	22 MPG	18 MPG	28 MPG	$3,150
2018	2018 Mercedes-Benz S450 4matic	22 MPG	18 MPG	28 MPG	$3,150

How the Mercedes-Benz S450 4matic compares against the Large Cars class

Buyers usually compare the Mercedes-Benz S450 4matic against other cars in the same EPA class. The list below shows the most efficient cars in the Large Cars class for the 2020 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.