Mercedes-Benz S450 MPG and Fuel Economy

Mercedes-Benz have been manufacturing models of S450 for 3 years, with the latest vehicle in 2020 having a combined MPG of 22.

The estimated fuel cost for the 2020 Mercedes-Benz S450 is $3,350 per year.

Government regulators have estimated that value based on 15,000 miles driven per year, using regular gasoline, and a split of 55% city driving and 45% highway driving.

💵 Compared to an average vehicle over 5 years, you will spend $5,250 more on fuel driving a 2020 Mercedes-Benz S450.

🛢 The Mercedes-Benz S450 will consume roughly 14 barrels of petroleum per year, using the standard estimate of 15,000 miles per year.

💨 For every mile driven, the Mercedes-Benz S450 will emit 403 grams of CO2, which is about 6,045,000 grams of CO2 per year.

🌳 To help you understand the impact of this, a normal tree will absorb around 21,000 grams of CO2 per year. This means that roughly 288 trees would be needed to offset emissions from the Mercedes-Benz S450.

The table below is a complete list of the 3 Mercedes-Benz S450 fuel efficiency specifications we have data for.

Click any vehicle link to see a more detailed breakdown of the car, miles per gallon, emissions, and more.

VehicleCombined MPGFuel Cost
2020 Mercedes-Benz S45022$3,350
2019 Mercedes-Benz S45022$3,350
2018 Mercedes-Benz S45022$3,350

Link To or Reference This Page

If you use this page in your research, please reference MPG Buddy as the source.

  • "Mercedes-Benz S450 MPG and Fuel Economy." MPG Buddy. Accessed on January 3, 2026. https://mpgbuddy.com/cars/mercedes-benz/s450.

  • "Mercedes-Benz S450 MPG and Fuel Economy." MPG Buddy, https://mpgbuddy.com/cars/mercedes-benz/s450. Accessed January 3, 2026.

  • Mercedes-Benz S450 MPG and Fuel Economy. MPG Buddy. Retrieved from https://mpgbuddy.com/cars/mercedes-benz/s450.