Pick a year below to open the full Mercedes-Benz S420 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz S420. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
1999 1999 Mercedes-Benz S420 16 MPG 14 MPG 20 MPG $4,300
1998 1998 Mercedes-Benz S420 16 MPG 14 MPG 20 MPG $4,300
1997 1997 Mercedes-Benz S420 16 MPG 14 MPG 20 MPG $4,300
1996 1996 Mercedes-Benz S420 16 MPG 14 MPG 20 MPG $4,300
1995 1995 Mercedes-Benz S420 16 MPG 14 MPG 19 MPG $4,300
1994 1994 Mercedes-Benz S420 15 MPG 14 MPG 18 MPG $4,600

How the Mercedes-Benz S420 compares against the Large Cars class

Buyers usually compare the Mercedes-Benz S420 against other cars in the same EPA class. The list below shows the most efficient cars in the Large Cars class for the 1999 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.