Pick a year below to open the full Mercedes-Benz ML350 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz ML350. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2015 2015 Mercedes-Benz ML350 20 MPG 18 MPG 23 MPG $3,450
2014 2014 Mercedes-Benz ML350 20 MPG 18 MPG 23 MPG $3,450
2013 2013 Mercedes-Benz ML350 20 MPG 18 MPG 23 MPG $3,450
2011 2011 Mercedes-Benz ML350 17 MPG 16 MPG 21 MPG $4,050
2010 2010 Mercedes-Benz ML350 18 MPG 16 MPG 21 MPG $3,850
2009 2009 Mercedes-Benz ML350 18 MPG 16 MPG 21 MPG $3,850
2006 2006 Mercedes-Benz ML350 16 MPG 14 MPG 19 MPG $4,300
2005 2005 Mercedes-Benz ML350 15 MPG 14 MPG 17 MPG $4,600
2004 2004 Mercedes-Benz ML350 15 MPG 14 MPG 17 MPG $4,600
2003 2003 Mercedes-Benz ML350 15 MPG 14 MPG 17 MPG $4,600

How the Mercedes-Benz ML350 compares against the Standard Sport Utility Vehicle 2WD class

Buyers usually compare the Mercedes-Benz ML350 against other cars in the same EPA class. The list below shows the most efficient cars in the Standard Sport Utility Vehicle 2WD class for the 2015 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.