Pick a year below to open the full Mercedes-Benz GLE350 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz GLE350. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2026 2026 Mercedes-Benz GLE350 23 MPG 21 MPG 28 MPG $3,000
2025 2025 Mercedes-Benz GLE350 23 MPG 21 MPG 28 MPG $3,000
2024 2024 Mercedes-Benz GLE350 24 MPG 21 MPG 28 MPG $2,900
2023 2023 Mercedes-Benz GLE350 22 MPG 20 MPG 25 MPG $3,150
2022 2022 Mercedes-Benz GLE350 22 MPG 19 MPG 27 MPG $3,150
2021 2021 Mercedes-Benz GLE350 22 MPG 19 MPG 26 MPG $3,150
2020 2020 Mercedes-Benz GLE350 22 MPG 20 MPG 27 MPG $3,150
2018 2018 Mercedes-Benz GLE350 20 MPG 18 MPG 23 MPG $3,450
2017 2017 Mercedes-Benz GLE350 20 MPG 18 MPG 23 MPG $3,450
2016 2016 Mercedes-Benz GLE350 20 MPG 18 MPG 23 MPG $3,450

How the Mercedes-Benz GLE350 compares against the Small Sport Utility Vehicle 4WD class

Buyers usually compare the Mercedes-Benz GLE350 against other cars in the same EPA class. The list below shows the most efficient cars in the Small Sport Utility Vehicle 4WD class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.