This page collects every fuel-economy figure the EPA publishes for the 2025 Mercedes-Benz EQS 450 4matic. Below you will find the headline combined, city, and highway MPG, the estimated annual fuel cost at three different driving levels, the tailpipe CO₂ emissions, and a full breakdown of the engine and drivetrain. If you want to know whether this generation got more or less efficient over the years, the year-over-year table further down covers every model year the EPA has rated.

Key takeaways

  • Returns 55% better combined MPG than the average car in the Large Cars class for the 2025 model year (59.5 MPG class average).
  • The most efficient car in the Large Cars class for the 2025 model year is the Lucid Air Pure RWD with 19 inch wheels at 146 MPG.
  • The Mercedes-Benz EQS 450 4matic has lost 11 MPG since its first rated model year, the 2023 Mercedes-Benz EQS 450 4matic at 103 MPG. That is often a sign of larger engines or heavier curb weights in newer generations.
  • EPA estimates this car saves around $6,500 in fuel over five years compared with an average new vehicle of the same model year.
  • Has an EPA-rated electric driving range of 367 miles, which is above the typical range for new electric vehicles.

Fuel economy at a glance

These are the EPA's official ratings for the 2025 Mercedes-Benz EQS 450 4matic. The numbers come from a standardised laboratory test cycle and are the same figures that appear on the window sticker of every new car. Real-world mileage varies with driving style, weather, fuel quality, and how heavily loaded the car is.

Combined MPG is a 55/45 weighted blend of the city and highway test cycles. The EPA uses it as the single number you can compare across the entire dataset, including hybrids and EVs (which use the equivalent MPGe figure).

Combined MPG 92 MPG
City MPG 91 MPG
Highway MPG 93 MPG
Annual fuel cost $850
Tailpipe CO₂
Fuel type Electricity

How the 2025 Mercedes-Benz EQS 450 4matic compares

The 2025 Mercedes-Benz EQS 450 4matic returns 92 combined MPG. Cars in the Large Cars class for the same model year average 59.5 MPG, which puts this car ahead of the class average by about 55%.

The most efficient car in the Large Cars class for the 2025 model year is the Lucid Air Pure RWD with 19 inch wheels at 146 MPG. The bar chart below puts the Mercedes-Benz EQS 450 4matic alongside the class best and the class average so you can see the full picture.

For broader context, the average new car of the 2025 model year (across all classes) returns 44.3 MPG. Larger vehicles pull the all-cars average down, so do not use that figure on its own to judge a small car or a hybrid. The full list of the most efficient cars of the 2025 model year is on its own page.

2025 Mercedes-Benz EQS 450 4matic
92 MPG
Class average, 2025
59.5 MPG
Class best, 2025
146 MPG
Average new car, 2025
44.3 MPG

Annual fuel cost across driving patterns

The headline annual fuel cost the EPA publishes assumes 15,000 miles of driving per year and a fuel mix of 55% city and 45% highway. The dollar figure is calculated using the EPA's current reference price for electricity, which is $0.15/kilowatt-hour. EPA updates that reference periodically rather than tracking live pump prices, so treat it as a window-sticker estimate rather than today's pump number.

The table below scales the EPA's number to three common driving patterns. The combined MPGe and the reference electricity price stay constant, only the annual mileage changes. Charging at home rather than at a public DC fast charger usually lowers the real cost below the EPA's published figure.

Driving pattern Estimated annual fuel cost
Light driver, 7,500 miles per year $425
Average driver, 15,000 miles per year $850
Heavy driver, 25,000 miles per year $1,417

Year-over-year MPG for the Mercedes-Benz EQS 450 4matic

The EPA has rated the Mercedes-Benz EQS 450 4matic across 4 model years, from 2023 Mercedes-Benz EQS 450 4matic through 2026 Mercedes-Benz EQS 450 4matic. The numbers below are the best combined MPG figure the EPA published for each year, which lets you see when the car was at its most efficient and how recent generations stack up.

The 2023 Mercedes-Benz EQS 450 4matic returned 103 MPG. The most recent 2026 Mercedes-Benz EQS 450 4matic returns 92 MPG. That is a drop of 11 MPG over 3 model years. Newer trims that grow heavier or carry larger engines tend to lose efficiency even as the rest of the lineup improves.

Year Combined MPG Open year page
2026 92 MPG 2026 Mercedes-Benz EQS 450 4matic
2025 92 MPG this page
2024 95 MPG 2024 Mercedes-Benz EQS 450 4matic
2023 103 MPG 2023 Mercedes-Benz EQS 450 4matic

Compare against other Large Cars for 2025

If you are cross-shopping the 2025 Mercedes-Benz EQS 450 4matic, the most useful comparison is against the other cars in the Large Cars class for the same model year. The list below shows the highest-MPG peers, ranked from most to least efficient. Click any of them to open its full page.

The Lucid Air Pure RWD with 19 inch wheels leads this group at 146 MPG, 54 MPG ahead of the 2025 Mercedes-Benz EQS 450 4matic.

Specifications

The 2025 Mercedes-Benz EQS 450 4matic is a fully electric vehicle. It is powered by 174 and 310 kw acpm 3-phase. The EPA rates its driving range at 367 miles.

Engine, transmission, and drivetrain together drive most of the variation in fuel economy across trims. A larger engine moves the car with less effort but burns more fuel. A turbo lets a small engine punch above its weight, often without much MPG penalty. All-wheel drive adds traction and weight, and usually costs a couple of MPG compared with two-wheel drive of the same engine.

Vehicle class
Large Cars
Transmission
Automatic (A1)
Drivetrain
All-Wheel Drive
Fuel type
Electricity
Electric motor
174 and 310 kW ACPM 3-Phase
EV range
367 miles
Annual petroleum use
0.1 barrels per year
Start-stop system
Yes

Common questions about the 2025 Mercedes-Benz EQS 450 4matic

Quick answers to the questions people most often search for when looking up the 2025 Mercedes-Benz EQS 450 4matic.

  • Is the 2025 Mercedes-Benz EQS 450 4matic fuel efficient?
    Yes. The 2025 Mercedes-Benz EQS 450 4matic returns 92 combined MPG, which beats the average car in the Large Cars class for the same model year by about 55%.
  • What MPG does the 2025 Mercedes-Benz EQS 450 4matic get?
    The EPA rates the 2025 Mercedes-Benz EQS 450 4matic at 92 combined MPG, 91 MPG in city driving, and 93 MPG on the highway. Real-world numbers depend on your driving style, the weather, and how loaded the car is.
  • How much does it cost to fuel a 2025 Mercedes-Benz EQS 450 4matic per year?
    The EPA estimates an annual fuel cost of $850 for the 2025 Mercedes-Benz EQS 450 4matic. That figure assumes 15,000 miles of driving per year, a 55% city and 45% highway split, and the EPA's published average fuel price for the rated fuel grade.
  • Does the 2025 Mercedes-Benz EQS 450 4matic use gasoline?
    No. The 2025 Mercedes-Benz EQS 450 4matic is fully electric and runs on grid electricity. The MPGe figure on this page converts electricity use into a gasoline-equivalent so you can compare it directly to a regular car.
  • Has the Mercedes-Benz EQS 450 4matic become more fuel efficient over time?
    Combined MPG has actually slipped. The first EPA-rated Mercedes-Benz EQS 450 4matic, the 2023 Mercedes-Benz EQS 450 4matic, returned 103 MPG, while the most recent 2026 Mercedes-Benz EQS 450 4matic returns 92 MPG. A drop of 11 MPG usually traces back to bigger engines or heavier curb weights in newer trims.
  • How much CO₂ does the 2025 Mercedes-Benz EQS 450 4matic emit?
    The 2025 Mercedes-Benz EQS 450 4matic produces zero tailpipe emissions because it runs entirely on electricity. The full carbon footprint of charging it depends on how the electricity on your local grid is generated, which varies a lot from one state to another.
  • What is the difference between the city and highway MPG of the 2025 Mercedes-Benz EQS 450 4matic?
    City driving returns 91 MPG and highway driving returns 93 MPG, a gap of 2 MPG. The two figures are close enough that the car will hold its rated efficiency well across most driving patterns.
  • What motor does the 2025 Mercedes-Benz EQS 450 4matic use?
    The 2025 Mercedes-Benz EQS 450 4matic uses 174 and 310 kW ACPM 3-Phase. Electric motors do not have a displacement or cylinder count the way a combustion engine does, so EPA reporting focuses on the motor type and battery system instead.
  • What transmission and drivetrain does the 2025 Mercedes-Benz EQS 450 4matic have?
    The 2025 Mercedes-Benz EQS 450 4matic comes with a automatic (a1) transmission and all-wheel drive. All-wheel-drive variants typically read 1 to 3 MPG lower than the front-wheel-drive equivalent of the same engine, since the extra hardware adds weight and parasitic loss.
  • How does the 2025 Mercedes-Benz EQS 450 4matic compare to the best car in its class?
    The most efficient car in the Large Cars class for the 2025 model year is the Lucid Air Pure RWD with 19 inch wheels at 146 combined MPG. The Mercedes-Benz EQS 450 4matic returns 92 MPG, a gap of 54 MPG. If you are comparing on fuel economy alone, the class leader is worth a look.

Source: U.S. EPA fuel economy dataset. Annual fuel cost figures assume 15,000 miles of driving per year and a 55% city, 45% highway split. Real-world mileage varies with driving conditions, vehicle maintenance, fuel quality, and driver behaviour.