Pick a year below to open the full Mercedes-Benz E550 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E550. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2011 2011 Mercedes-Benz E550 18 MPG 15 MPG 23 MPG $3,850
2010 2010 Mercedes-Benz E550 18 MPG 16 MPG 24 MPG $3,850
2009 2009 Mercedes-Benz E550 17 MPG 15 MPG 22 MPG $4,050
2008 2008 Mercedes-Benz E550 17 MPG 15 MPG 22 MPG $4,050
2007 2007 Mercedes-Benz E550 16 MPG 14 MPG 21 MPG $4,300

How the Mercedes-Benz E550 compares against the Midsize Cars class

Buyers usually compare the Mercedes-Benz E550 against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Cars class for the 2011 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.