Pick a year below to open the full Mercedes-Benz E450 Coupe page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E450 Coupe. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2023 2023 Mercedes-Benz E450 Coupe 25 MPG 23 MPG 30 MPG $2,750
2022 2022 Mercedes-Benz E450 Coupe 25 MPG 22 MPG 29 MPG $2,750
2021 2021 Mercedes-Benz E450 Coupe 26 MPG 23 MPG 31 MPG $2,650
2020 2020 Mercedes-Benz E450 Coupe 23 MPG 20 MPG 28 MPG $3,000
2019 2019 Mercedes-Benz E450 Coupe 23 MPG 20 MPG 28 MPG $3,000

How the Mercedes-Benz E450 Coupe compares against the Subcompact Cars class

Buyers usually compare the Mercedes-Benz E450 Coupe against other cars in the same EPA class. The list below shows the most efficient cars in the Subcompact Cars class for the 2023 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.