Mercedes-Benz E450 4matic Coupe: MPG and fuel economy by year

The EPA has rated the Mercedes-Benz E450 4matic Coupe across 5 model years, from the 2019 Mercedes-Benz E450 4matic Coupe through the 2023 Mercedes-Benz E450 4matic Coupe. The most recent 2023 Mercedes-Benz E450 4matic Coupe returns 24 combined MPG. The most efficient model year was the 2021 Mercedes-Benz E450 4matic Coupe at 25 MPG.

Pick a year below to open the full Mercedes-Benz E450 4matic Coupe page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E450 4matic Coupe. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year	Model	Combined MPG	City	Highway	Annual fuel cost
2023	2023 Mercedes-Benz E450 4matic Coupe	24 MPG	21 MPG	30 MPG	$2,900
2022	2022 Mercedes-Benz E450 4matic Coupe	24 MPG	21 MPG	30 MPG	$2,900
2021	2021 Mercedes-Benz E450 4matic Coupe	25 MPG	23 MPG	30 MPG	$2,750
2020	2020 Mercedes-Benz E450 4matic Coupe	22 MPG	19 MPG	26 MPG	$3,150
2019	2019 Mercedes-Benz E450 4matic Coupe	22 MPG	19 MPG	26 MPG	$3,150

How the Mercedes-Benz E450 4matic Coupe compares against the Subcompact Cars class

Buyers usually compare the Mercedes-Benz E450 4matic Coupe against other cars in the same EPA class. The list below shows the most efficient cars in the Subcompact Cars class for the 2023 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.