Mercedes-Benz E450 4matic All-Terrain (wagon): MPG and fuel economy by year
The EPA has rated the Mercedes-Benz E450 4matic All-Terrain (wagon) across 6 model years, from the 2021 Mercedes-Benz E450 4matic All-Terrain (wagon) through the 2026 Mercedes-Benz E450 4matic All-Terrain (wagon). The most recent 2026 Mercedes-Benz E450 4matic All-Terrain (wagon) returns 25 combined MPG.
Pick a year below to open the full Mercedes-Benz E450 4matic All-Terrain (wagon) page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.
Fuel economy by model year
Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E450 4matic All-Terrain (wagon). Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.
| Year | Model | Combined MPG | City | Highway | Annual fuel cost |
|---|---|---|---|---|---|
| 2026 | 2026 Mercedes-Benz E450 4matic All-Terrain (wagon) | 25 MPG | 22 MPG | 31 MPG | $2,750 |
| 2025 | 2025 Mercedes-Benz E450 4matic All-Terrain (wagon) | 25 MPG | 22 MPG | 31 MPG | $2,750 |
| 2024 | 2024 Mercedes-Benz E450 4matic All-Terrain (wagon) | 25 MPG | 22 MPG | 31 MPG | $2,750 |
| 2023 | 2023 Mercedes-Benz E450 4matic All-Terrain (wagon) | 24 MPG | 21 MPG | 28 MPG | $2,900 |
| 2022 | 2022 Mercedes-Benz E450 4matic All-Terrain (wagon) | 24 MPG | 21 MPG | 28 MPG | $2,900 |
| 2021 | 2021 Mercedes-Benz E450 4matic All-Terrain (wagon) | 24 MPG | 22 MPG | 28 MPG | $2,900 |
How the Mercedes-Benz E450 4matic All-Terrain (wagon) compares against the Midsize Station Wagons class
Buyers usually compare the Mercedes-Benz E450 4matic All-Terrain (wagon) against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Station Wagons class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.
Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.