Mercedes-Benz E450 4matic: MPG and fuel economy by year
The EPA has rated the Mercedes-Benz E450 4matic across 8 model years, from the 2019 Mercedes-Benz E450 4matic through the 2026 Mercedes-Benz E450 4matic. The most recent 2026 Mercedes-Benz E450 4matic returns 25 combined MPG. The most efficient model year was the 2023 Mercedes-Benz E450 4matic at 26 MPG.
Pick a year below to open the full Mercedes-Benz E450 4matic page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.
Fuel economy by model year
Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E450 4matic. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.
| Year | Model | Combined MPG | City | Highway | Annual fuel cost |
|---|---|---|---|---|---|
| 2026 | 2026 Mercedes-Benz E450 4matic | 25 MPG | 22 MPG | 31 MPG | $2,750 |
| 2025 | 2025 Mercedes-Benz E450 4matic | 25 MPG | 22 MPG | 31 MPG | $2,750 |
| 2024 | 2024 Mercedes-Benz E450 4matic | 25 MPG | 22 MPG | 31 MPG | $2,750 |
| 2023 | 2023 Mercedes-Benz E450 4matic | 26 MPG | 23 MPG | 31 MPG | $2,650 |
| 2022 | 2022 Mercedes-Benz E450 4matic | 25 MPG | 23 MPG | 30 MPG | $2,750 |
| 2021 | 2021 Mercedes-Benz E450 4matic | 26 MPG | 23 MPG | 30 MPG | $2,650 |
| 2020 | 2020 Mercedes-Benz E450 4matic | 23 MPG | 20 MPG | 28 MPG | $3,000 |
| 2019 | 2019 Mercedes-Benz E450 4matic | 23 MPG | 20 MPG | 28 MPG | $3,000 |
How the Mercedes-Benz E450 4matic compares against the Midsize Cars class
Buyers usually compare the Mercedes-Benz E450 4matic against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Cars class for the 2026 model year, the latest year on this page. Each link opens the full page for that car.
Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.