Pick a year below to open the full Mercedes-Benz E400 4matic (station wagon) page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E400 4matic (station wagon). Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2018 2018 Mercedes-Benz E400 4matic (station wagon) 21 MPG 19 MPG 25 MPG $3,300
2017 2017 Mercedes-Benz E400 4matic (station wagon) 21 MPG 19 MPG 25 MPG $3,300
2015 2015 Mercedes-Benz E400 4matic (station wagon) 22 MPG 19 MPG 26 MPG $3,150

How the Mercedes-Benz E400 4matic (station wagon) compares against the Midsize Station Wagons class

Buyers usually compare the Mercedes-Benz E400 4matic (station wagon) against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Station Wagons class for the 2018 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.