Mercedes-Benz E350 (wagon): MPG and fuel economy by year

The EPA has rated the Mercedes-Benz E350 (wagon) for one model year, the 2006 Mercedes-Benz E350 (wagon). The most recent 2006 Mercedes-Benz E350 (wagon) returns 19 combined MPG.

Pick a year below to open the full Mercedes-Benz E350 (wagon) page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E350 (wagon). Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year	Model	Combined MPG	City	Highway	Annual fuel cost
2006	2006 Mercedes-Benz E350 (wagon)	19 MPG	16 MPG	24 MPG	$3,650

How the Mercedes-Benz E350 (wagon) compares against the Midsize Station Wagons class

Buyers usually compare the Mercedes-Benz E350 (wagon) against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Station Wagons class for the 2006 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.