Mercedes-Benz E350 4matic (wagon): MPG and fuel economy by year
The EPA has rated the Mercedes-Benz E350 4matic (wagon) across 10 model years, from the 2006 Mercedes-Benz E350 4matic (wagon) through the 2016 Mercedes-Benz E350 4matic (wagon). The most recent 2016 Mercedes-Benz E350 4matic (wagon) returns 22 combined MPG.
Pick a year below to open the full Mercedes-Benz E350 4matic (wagon) page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.
Fuel economy by model year
Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz E350 4matic (wagon). Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.
| Year | Model | Combined MPG | City | Highway | Annual fuel cost |
|---|---|---|---|---|---|
| 2016 | 2016 Mercedes-Benz E350 4matic (wagon) | 22 MPG | 20 MPG | 26 MPG | $3,150 |
| 2015 | 2015 Mercedes-Benz E350 4matic (wagon) | 22 MPG | 20 MPG | 26 MPG | $3,150 |
| 2014 | 2014 Mercedes-Benz E350 4matic (wagon) | 22 MPG | 20 MPG | 26 MPG | $3,150 |
| 2013 | 2013 Mercedes-Benz E350 4matic (wagon) | 22 MPG | 19 MPG | 27 MPG | $3,150 |
| 2012 | 2012 Mercedes-Benz E350 4matic (wagon) | 22 MPG | 19 MPG | 27 MPG | $3,150 |
| 2011 | 2011 Mercedes-Benz E350 4matic (wagon) | 19 MPG | 16 MPG | 23 MPG | $3,650 |
| 2009 | 2009 Mercedes-Benz E350 4matic (wagon) | 18 MPG | 16 MPG | 21 MPG | $3,850 |
| 2008 | 2008 Mercedes-Benz E350 4matic (wagon) | 18 MPG | 16 MPG | 21 MPG | $3,850 |
| 2007 | 2007 Mercedes-Benz E350 4matic (wagon) | 18 MPG | 16 MPG | 22 MPG | $3,850 |
| 2006 | 2006 Mercedes-Benz E350 4matic (wagon) | 18 MPG | 16 MPG | 22 MPG | $3,850 |
How the Mercedes-Benz E350 4matic (wagon) compares against the Midsize Station Wagons class
Buyers usually compare the Mercedes-Benz E350 4matic (wagon) against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Station Wagons class for the 2016 model year, the latest year on this page. Each link opens the full page for that car.
Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.