Pick a year below to open the full Mercedes-Benz CLS550 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz CLS550. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2018 2018 Mercedes-Benz CLS550 21 MPG 18 MPG 26 MPG $3,300
2017 2017 Mercedes-Benz CLS550 21 MPG 18 MPG 26 MPG $3,300
2016 2016 Mercedes-Benz CLS550 20 MPG 18 MPG 26 MPG $3,450
2015 2015 Mercedes-Benz CLS550 20 MPG 18 MPG 26 MPG $3,450
2014 2014 Mercedes-Benz CLS550 20 MPG 17 MPG 25 MPG $3,450
2013 2013 Mercedes-Benz CLS550 20 MPG 17 MPG 25 MPG $3,450
2012 2012 Mercedes-Benz CLS550 20 MPG 17 MPG 25 MPG $3,450
2011 2011 Mercedes-Benz CLS550 16 MPG 14 MPG 21 MPG $4,300
2010 2010 Mercedes-Benz CLS550 16 MPG 14 MPG 21 MPG $4,300
2009 2009 Mercedes-Benz CLS550 16 MPG 14 MPG 21 MPG $4,300
2008 2008 Mercedes-Benz CLS550 16 MPG 14 MPG 21 MPG $4,300
2007 2007 Mercedes-Benz CLS550 16 MPG 14 MPG 20 MPG $4,300

How the Mercedes-Benz CLS550 compares against the Compact Cars class

Buyers usually compare the Mercedes-Benz CLS550 against other cars in the same EPA class. The list below shows the most efficient cars in the Compact Cars class for the 2018 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.