Mercedes-Benz CLS450 MPG and Fuel Economy

Mercedes-Benz have been manufacturing models of CLS450 for 3 years, with the latest vehicle in 2021 having a combined MPG of 26.

The estimated fuel cost for the 2021 Mercedes-Benz CLS450 is $2,850 per year.

Government regulators have estimated that value based on 15,000 miles driven per year, using regular gasoline, and a split of 55% city driving and 45% highway driving.

💵 Compared to an average vehicle over 5 years, you will spend $2,750 more on fuel driving a 2021 Mercedes-Benz CLS450.

🛢 The Mercedes-Benz CLS450 will consume roughly 11 barrels of petroleum per year, using the standard estimate of 15,000 miles per year.

💨 For every mile driven, the Mercedes-Benz CLS450 will emit 347 grams of CO2, which is about 5,205,000 grams of CO2 per year.

🌳 To help you understand the impact of this, a normal tree will absorb around 21,000 grams of CO2 per year. This means that roughly 248 trees would be needed to offset emissions from the Mercedes-Benz CLS450.

The table below is a complete list of the 3 Mercedes-Benz CLS450 fuel efficiency specifications we have data for.

Click any vehicle link to see a more detailed breakdown of the car, miles per gallon, emissions, and more.

VehicleCombined MPGFuel Cost
2021 Mercedes-Benz CLS45026$2,850
2020 Mercedes-Benz CLS45026$2,850
2019 Mercedes-Benz CLS45026$2,850

Link To or Reference This Page

If you use this page in your research, please reference MPG Buddy as the source.

  • "Mercedes-Benz CLS450 MPG and Fuel Economy." MPG Buddy. Accessed on January 3, 2026. https://mpgbuddy.com/cars/mercedes-benz/cls450.

  • "Mercedes-Benz CLS450 MPG and Fuel Economy." MPG Buddy, https://mpgbuddy.com/cars/mercedes-benz/cls450. Accessed January 3, 2026.

  • Mercedes-Benz CLS450 MPG and Fuel Economy. MPG Buddy. Retrieved from https://mpgbuddy.com/cars/mercedes-benz/cls450.