Mercedes-Benz CLS450: MPG and fuel economy by year

The EPA has rated the Mercedes-Benz CLS450 across 3 model years, from the 2019 Mercedes-Benz CLS450 through the 2021 Mercedes-Benz CLS450. The most recent 2021 Mercedes-Benz CLS450 returns 26 combined MPG.

Pick a year below to open the full Mercedes-Benz CLS450 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz CLS450. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year	Model	Combined MPG	City	Highway	Annual fuel cost
2021	2021 Mercedes-Benz CLS450	26 MPG	23 MPG	30 MPG	$2,650
2020	2020 Mercedes-Benz CLS450	26 MPG	24 MPG	31 MPG	$2,650
2019	2019 Mercedes-Benz CLS450	26 MPG	24 MPG	31 MPG	$2,650

How the Mercedes-Benz CLS450 compares against the Compact Cars class

Buyers usually compare the Mercedes-Benz CLS450 against other cars in the same EPA class. The list below shows the most efficient cars in the Compact Cars class for the 2021 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.