Pick a year below to open the full Mercedes-Benz C280 page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz C280. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2007 2007 Mercedes-Benz C280 22 MPG 19 MPG 26 MPG $3,150
2006 2006 Mercedes-Benz C280 21 MPG 18 MPG 26 MPG $3,300
2000 2000 Mercedes-Benz C280 21 MPG 19 MPG 25 MPG $3,300
1999 1999 Mercedes-Benz C280 21 MPG 19 MPG 25 MPG $3,300
1998 1998 Mercedes-Benz C280 21 MPG 18 MPG 25 MPG $3,300
1997 1997 Mercedes-Benz C280 20 MPG 18 MPG 24 MPG $3,450
1996 1996 Mercedes-Benz C280 19 MPG 17 MPG 24 MPG $3,650
1995 1995 Mercedes-Benz C280 20 MPG 18 MPG 24 MPG $3,450
1994 1994 Mercedes-Benz C280 20 MPG 18 MPG 24 MPG $3,450

How the Mercedes-Benz C280 compares against the Compact Cars class

Buyers usually compare the Mercedes-Benz C280 against other cars in the same EPA class. The list below shows the most efficient cars in the Compact Cars class for the 2007 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.