Pick a year below to open the full Mercedes-Benz AMG S63 E Performance page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Mercedes-Benz AMG S63 E Performance. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year Model Combined MPG City Highway Annual fuel cost
2025 2025 Mercedes-Benz AMG S63 E Performance 18 MPG 15 MPG 23 MPG $3,850

How the Mercedes-Benz AMG S63 E Performance compares against the Midsize Cars class

Buyers usually compare the Mercedes-Benz AMG S63 E Performance against other cars in the same EPA class. The list below shows the most efficient cars in the Midsize Cars class for the 2025 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.