Audi A4 S line quattro: MPG and fuel economy by year

The EPA has rated the Audi A4 S line quattro across 5 model years, from the 2021 Audi A4 S line quattro through the 2025 Audi A4 S line quattro. The most recent 2025 Audi A4 S line quattro returns 26 combined MPG. The most efficient model year was the 2024 Audi A4 S line quattro at 27 MPG.

Pick a year below to open the full Audi A4 S line quattro page for that model year. Each year page covers combined, city, and highway MPG, the trim variants the EPA rates separately, the annual fuel cost across three driving patterns, and a year-over-year comparison so you can see whether the car has improved.

Fuel economy by model year

Combined MPG, city MPG, highway MPG, and the EPA's estimated annual fuel cost for every model year of the Audi A4 S line quattro. Click any year to see the full breakdown for that model year, including trim variants, the drivetrain, and a comparison against other vehicles in its segment.

Year	Model	Combined MPG	City	Highway	Annual fuel cost
2025	2025 Audi A4 S line quattro	26 MPG	23 MPG	32 MPG	$2,650
2024	2024 Audi A4 S line quattro	27 MPG	24 MPG	32 MPG	$2,550
2023	2023 Audi A4 S-Line quattro	27 MPG	24 MPG	32 MPG	$2,550
2022	2022 Audi A4 S line quattro	27 MPG	24 MPG	31 MPG	$2,550
2021	2021 Audi A4 S line quattro	27 MPG	24 MPG	31 MPG	$2,550

How the Audi A4 S line quattro compares against the Compact Cars class

Buyers usually compare the Audi A4 S line quattro against other cars in the same EPA class. The list below shows the most efficient cars in the Compact Cars class for the 2025 model year, the latest year on this page. Each link opens the full page for that car.

Source: U.S. EPA fuel economy dataset. Annual fuel cost assumes 15,000 miles of driving per year and a 55% city, 45% highway split.